Tłumaczenie przysięgłe: tak Język oryginału: angielski Język tłumaczenia: polski Liczba stron do przetłumaczenia: 1-2 Tłumaczenie: dokumentów naukowych Charakter zlecenia: jednorazowe Termin realizacji: w ciągu miesiąca Dodatkowe informacje: Simple Summary: CD38 remains an interesting target for anticancer therapy. Its relatively high abundance in neoplasms and crucial impact on NAD+/cADPR metabolism and the activity of T cells allows for changing the immune response in autoimmune diseases, neoplasms, and finally the induction of cell death. Antibody-dependent cell cytotoxicity is responsible for cell death induced by targeting the tumor with anti-CD38 antibodies, such as daratumumab. A wide range of laboratory experiments and clinical trials show an especially promising role of anti-CD38 therapy against multiple myeloma, NK cell lymphomas, and CD19- B-cell malignancies. More studies are required to include more diseases in the therapeutic protocols involving the modulation of CD38 activity.